Synthesis of 5-(6-hydroxy-7H-purine-8-ylthio)- 2-(N-hydroxyformamido)pentanoic acid

• Yanmei Zhang,
• Greg Elliot,
• Adrian Saldanha,
• Igor Tsigelny,
• Dennis Carson and
• Wolf Wrasidlo

Beilstein J. Org. Chem. 2010, 6, 742–747, doi:10.3762/bjoc.6.93

• thiolated nucleoside to obtain the hybrid model compound. Keywords: adenylosuccinate synthetase (AdSS); thiolated nucleoside; Introduction During cell proliferation, adenine nucleotides for nucleic acid synthesis are generated through a de novo biosynthetic route, which requires the key enzyme

• adenylosuccinate synthetase (AdSS). Adenine nucleotides are also recycled by a salvage pathway which requires methylthioadenosine phosphorylase (MTAP). In some cancers this salvage pathway is lost making these cancers hypersensitive to cytotoxic effects of pharmacologic AdSS inhibitors [1]. However, no direct